Figure 1
From: Nef gene evolution from a single transmitted strain in acute SIV infection
Nucleotide and amino acid base substitutions within 3 weeks post SIV infection. Longitudinal nucleotide (A) and amino acid (B) base substitutions from the founder nef gene/Nef protein of sequence samples taken at day 4, 7, 11 and 18 post-infection from animal r00065, which was infected intravenously with SIVmac239. C and D display base substitutions in reference to the founder sequence from the samples taken at day 7, 14, and 21 post-infection from animal r98018, which was infected by intrarectal inoculation with SIVmac239. Numbers in the left column in each figure represent the number of a specific sequence out of total sampled sequences at a given day post infection. Each clone was obtained via the method of single genome amplification.