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Figure 1 | Retrovirology

Figure 1

From: The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study

Figure 1

Synergistic inhibition of HIV-1 replication by combinations TFV+FTC, TFV+EFV, FTC+EFV, and TFV+FTC+EFV analyzed by the median-effect analysis. The solid line presents curve fitting of the CI values as a function of fractional effect. The dashed lines represent 95% confidence interval. The line (in red) at CI = 1 represents additivity. (A) TFV+FTC (1:1 IC50 ratio) with an average CI of 0.47; (B) TFV+EFV (1:1 IC50 ratio) with average CI of 0.54; (C) FTC+EFV (1:1 IC50 ratio) with an average CI of 0.62; (D) TFV+FTC+EFV (1:1:1 IC50 ratio) with an average CI of 0.46.

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Retrovirology

ISSN: 1742-4690

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