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Table 1 Evolution of positively selected amino acids that were rarely found in the 500 sequences database.

From: Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects

AA pos

Frequency in the database

A

B

C

D

E

F

G

  

I

II

III

I

II

III

I

II

III

I

II

III

I

II

III

I

II

III

I

II

III

269

Glu 76.8%

Asp 8.1%

E

  

E

  

E

  

D

15/15

D

15/15

D

10/13

E

  

E

  

D

19/19

D 9/14

D

9/10

             

E

3/13

       

E

5/14

E

1/10

339

Asn 78.5%

Asp 4.3%

His 0.5%

N

  

N

  

N

8/13

N

14/15

N

8/14

V

  

N

  

K

K

N

N

  
        

D

4/13

H

1/15

H

6/14

            
        

H

1/13

              

340

Lys 32.5%

Asn 31.3%

Asp 7.2%

E

  

D

16/16

D

3/15

N

10/10

D

  

K

  

N

  

N

  

N

  
      

N

12/15

                

341

Thr 91.4%

Ala 5.7%

T

  

T

  

T

  

T

13/15

T

5/12

T

1/3

T

  

T

  

T

  
           

A

2/15

A

7/12

A

12/13

         

343

Asn 2.4%

lys 25.9%

Gln 40.5%

Glu 9.6%

K

  

K

  

N

2/13

N

14/15

N

5/14

K

15/15

K

7/12

E

3/13

K

12/12

K

6/8

K

5/14

G

13/13

E

14/19

K

14/14

K

19/19

K

11/11

E

2/7

        

K

11/13

K

1/15

K

5/14

 

E

4/12

K

10/13

 

R

1/8

Q

8/14

 

R

5/19

   

Q

2/10

          

R

4/14

 

T

1/12

  

E

1/8

R

1/14

      

346

Val 37.6%

Ala 26.8%

Ser11.2%

Phe 0.2%

Tyr 0%

V

  

A

5/16

V

15/15

V

10/10

V

4/13

V

15/15

V

10/14

V

  

V

3/12

V

6/8

V

6/14

V

  

V

19/19

V

7/11

A

9/9

     

V

11/16

  

A

4/13

 

A

4/14

   

F

5/12

F

2/8

Y

8/14

    

A

4/11

 
              

A 4/12

        

394

Thr 81.3%

Iso 3.1%

Ala 1.7%

T

  

T

  

T

4/13

T

13/15

T

6/14

T

  

T

  

T

  

T

  
        

I 9/13

I 1/15

I 8/14

            
         

A 1/15

             

476

Arg 81.3%

Lys 18.4%

Met 0%

K

  

R

  

R 11/13

R 3/15

R 8/14

R

  

M

  

R

  

R

  
        

K 2/13

K 12/15

K 6/14

            
  1. Their frequency in the sequence database and their proportion (number of clones with the mutation/number of clones sequenced) in the viral quasispecies at each time point (I, II, and III) are shown.
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