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Figure 6 | Retrovirology

Figure 6

From: Conservation of Nef function across highly diverse lineages of SIVsmm

Figure 6

SIVsmm nef alleles inhibit NFAT induction. Analysis of Jurkat cells stably transfected with an NFAT-dependent reporter gene following transduction with the indicated HIV-1 Nef/eGFP constructs and subsequent stimulation with PHA. Levels of NFAT-dependent luciferase reporter activity are the average (± SD) of triple infections. The asterisks denote a statistical significance (P < 0.01) between HIV-1 and SIV Nef activity. Similar results were obtained in two independent experiments.

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