The Spanish HIV BioBank: a model of cooperative HIV research

Retrovirology

Table 1 Participating patients in sample donation to the HIV Research BioBank and the date of creation and the sample types donated and for each cohort.

Cohort		Creation's date	Sample Type	# of patients with samples in the BioBank
Adults^a)		3rd June 2004	Blood	2,865
LTNPs^b)		3rd June 2004	Blood	181
Rapid progressors^c)		7th February 2008	Blood	19
Non-regenerators^d)		5th February 2008	Blood	12
Recent infections^e)	90 days of HIV+	7th February 2008	Blood	13
	180 days of HIV+			15
OLT-HIV^f)		24th January 2008	Blood, liver and spleen biopsies	21

a) Cohort of Adults (CoRIS): includes patients older than 13 with a confirmed diagnosis of HIV-infection that have not received prior antiretroviral treatment and are being seen for the first time in the participating center; b) Cohort of Long Term Non-Progresors (LTNP): includes patients who have T-lymphocyte counts > 500/μL and undetectable viremia for more than 10 years; c) Cohort of Rapid Progressors: includes patients whose CD4 levels have fallen below 300 in less than 3 years after seroconversion and with a window of less than 3 years between the last negative and first positive HIV test; d) Cohort of Lymphocyte Non-Regenerators: includes patients who began HAART with T-lymphocyte < 200/μL that remained under observation with high activity antiretroviral therapy (HAART) treatment during a period of at least 2 years during which the viremia was consistently undetectable. At the conclusion of the observation period, their CD4 values must not have reached the critical level of 250 cells/μl and e) Cohort of Recent Infection: patients with a documented date of seroconversion less than 6 months prior; f) Cohort of HIV-infected patients with organ liver transplant (OLT-HIV): includes HIV-infected patients that have received a liver transplant primarily as a consequence of hepatitis C virus (VHC) induced cirrhosis.

ISSN: 1742-4690