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Figure 6 | Retrovirology

Figure 6

From: Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence

Figure 6

The mode of action of gp41e inhibition of fusion protein clustering. The exogenous gp41e trimer (green) interferes with Env recruitment. The resulting Env-gp41e complex blocks the formation of a functional pore and the progress to complete fusion because gp41e lacks a TMD and cytoplasmic tail needed for the disruption of inner leaflets of fusing membranes. This could be a mechanism of fusion inhibition by gp41e.

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