In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Table 1 HTLV-1 mRNA load, proviral load and mRNA/DNA ratio in HTLV-1 – infected individuals and T-cell lines.

Cell line	HBZ mRNA^a	tax mRNA^b	Proviral load^c	HBZ mRNA/DNA^d	tax mRNA/DNA^e
C5/MJ	13.3	0.062	8.1	1.64	0.0076
HUT102	1.2	26.35	19.3	0.063	1.37
MT1	25.2	0.011	7.1	3.56	0.0015
MT2	7.8	1.24	16.2	0.48	0.077
MT4	2.4	1.71	12.6	0.19	0.135
SLB1	25.8	87.4	115.5	0.22	0.756
HAM/TSP*	0.74 (0.023–33.50)	0 (0–0.041)	0.051 (0.0008–0.41)	19.10 (0.81–273.45)	0 (0–0.32)
HCs*	0.15 (0.0013–6.42)	0 (0–0.000078)	0.0089 (0.0001–0.10)	16.67 (0.21–7358.91)	0 (0–0.11)
ATL*	31.43 (5.93–225.64)	0.000018 (0–0.59)	1.14 (0.25–2.88)	24.04 (13.77–135.83)	0 (0–0.29)

*The results represent the median and range (n = 56 for HAM/TSP, n = 38 for HCs and n = 10 for ATL)
^aHTLV-1 HBZ mRNA load = value of HBZ/value of HPRT
^bHTLV-1 tax mRNA load = value of tax/value of HPRT
^cProviral load: HTLV-1 tax copy number per cell
^dHBZ mRNA/DNA ratio = HTLV-1 HBZ mRNA load/Proviral load
^etax mRNA/DNA ratio = HTLV-1 tax mRNA load/Proviral load

ISSN: 1742-4690