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Table 4 Vif/Vpr and Gag sequences containing G-to-A mutations that resulted in Stop/Start codon mutations, other mutations, or no mutations.

From: APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

Sample

Total Sequences with

Stop/Start Codon Mutations (%)

Total Sequences w/

Other Mutations (%)

Total Sequences w/

No Mutations (%)

Vif/Vpr

   

DNA

(Round 2 +3)

83 (59.7%)

30 (21.6%)

26 (18.2%)

Cellular Viral RNA

(Round 2+3)

24 (22.2%)

22 (20.4%)

62 (57.4%)

Virion RNA

(Round 2+3)

13 (10.2%)

16 (12.6%)

98 (77.2%)

Gag

   

DNA

(Round 2)

17 (70.8%)

2 (8.3%)

5 (20.8%)

Cellular Viral RNA

(Round 2)

26 (22.4%)

24 (20.7%)

66 (56.9%)

Virion RNA

(Round 2)

6 (6.3%)

12 (12.5%)

78 (81.3%)