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Table 3 Analysis of mutations in the Vif/Vpr and DIS/Gag regions.

From: APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

 

Vif/Vpr Region

DIS/Gag Region

 

HIV-1 WT

HIV-YRHHY>A5

HIV-YRHHY>A5

 

G-to-A Mutations/

Total G ntsa

Other Mutations/

Total ntsb

G-to-A Mutations/Total G nts

Other Mutations/

Total nts

G-to-A Mutations/

Total G ntsc

Other Mutations/

Total ntsd

DNA

4/3910

0/16,790

712/23,630

66/101,470

62/2856

14/9000

Cellular Viral RNA

0/2550

3/10,950

94/18,360

43/78,840

83/13,804

37/43,500

Virion RNA

22/12,580

14/54,020

49/21,590

82/92,710

27/11,424

15/36,000

  1. a Total G nucleotides (nts) in the Vif/Vpr region were 170 per sequence.
  2. b Total nucleotides in the Vif/Vpr region were 730 per sequence.
  3. c Total G nucleotides in the DIS/Gag region were 119 per sequence.
  4. d Total nucleotides in the DIS/Gag region were 375 per nucleotide.
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Retrovirology

ISSN: 1742-4690

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