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Table 2 Amino acid heterogeneity of V3 region of HIV-1 proviral quasispecies harboured by monocytes (CD36) and T lymphocytes (CD26) and of plasma virions replicating in the two cell types after HAART interruption.

From: Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lymphomonocyte sub-populations

Patient Sample type   N. of unique variants* Diversity** Complexity***
Pt.1 Provirus CD36 161 0.0795 ± 0.0005 0.3798
   CD26 226 0.0197 ± 0.0001 0.2119
Pt.2 Provirus CD36 231 0.1446 ± 0.0005 0.3620
   CD26 59 0.0031 ± 0.0001 0.0919
Pt.3 Provirus CD36 46 0.0508 ± 0.0003 0.3042
   CD26 3 0.0084 ± 0.0002 0.0738
  Virus CD36 26 0.0428 ± 0.0010 0.2979
   CD26 158 0.0298 ± 0.0003 0.3293
Pt.4 Provirus CD36 76 0.0226 ± 0.0007 0.1127
   CD26 14 0.0457 ± 0.0003 0.1755
  Virus CD36 15 0.0113 ± 0.0002 0.1138
   CD26 41 0.0208 ± 0.0002 0.1222
Pt.5 Provirus CD36 157 0.0585 ± 0.0003 0.2756
   CD26 120 0.0411 ± 0.0004 0.4233
  Virus CD36 305 0.0728 ± 0.0005 0.3664
   CD26 38 0.0042 ± 0.0001 0.0870
  1. Sequences obtained by ultra-deep pyrosequencing were filtered through the correction algorithm and amino acid sequences obtained were analyzed to establish diversity and complexity, as described in the Materials and Methods section.
  2. * Number of unique sequences obtained after dereplication
  3. ** Diversity: p distance ± SEM
  4. *** Complexity: normalized Shannon entropy