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Figure 2 | Retrovirology

Figure 2

From: Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

Figure 2

Important Sp transcription factor signaling in monocyte-macropahges. (a) Activation of HIV transcription by the interaction of viral protein Tat with DNA-dependent protein kinase (DNA-PK) results in the subsequent phosphorylation at Ser131 of Sp1. Phosphorylated Sp1 results in increased transcription of proviral DNA, resulting in an increase in Tat production, perpetuating the cycle. (b) Inhibition of HIV transcription involves O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzing the addition of O-GlcNAC to Sp proteins which blocks their interaction with their binding sites on the LTR, resulting in an inhibition/reduction in HIV transcription.

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