T-cell receptor activation stimulates tumorigenesis in TAX-LUC-DO mice. A) Total number of tumors indicated by a single circle for each animal, with closed circles indicating mice immunized with CFA + OA and open circles indicating mice immunized with CFA alone. Red bars indicate the average number of tumors for each group. B) Survival curve for TAX-LUC-DO mice immunized with CFA and OA or CFA alone. C) FACS histograms of TCR expression in tumors that arose on the tail, small intestine, or ear of treated triple transgenics. D) Histology of tumors that infiltrated the spleen, lung, and liver as well as a comparison of gut and tail tumors. E) TCRova, CD16, and TAX expression in tail and gut tumors from a TAX-LUC-DO mouse.