Phorbol myristyl acetate stimulation of bioluminescence in transgenic mice. For each mouse, the left ear was treated with PMA and the right ear with vehicle. A) Representative images obtained 2 hours after treatment are shown for two LTR-LUC mice (left panels) and two TAX-LUC mice (right panels) comparing bioluminescence following administration of D-luciferin (top panels) and Luminol (bottom panel). B) Histology showing edema and inflammatory infiltrate associated with topical application of PMA (48 hours; Bar = 1 mm). C) Aggressive lymphoma in TAX-LUC mice from intravenous administration of con A. D) Histology is H/E stained sections of bioluminescent tumors in the cervical lymph nodes and small intestine of a con A treated TAX-LUC mouse.