Figure 2
From: T-cell activation promotes tumorigenesis in inflammation-associated cancer
Phorbol myristyl acetate stimulation of bioluminescence in transgenic mice. For each mouse, the left ear was treated with PMA and the right ear with vehicle. A) Representative images obtained 2 hours after treatment are shown for two LTR-LUC mice (left panels) and two TAX-LUC mice (right panels) comparing bioluminescence following administration of D-luciferin (top panels) and Luminol (bottom panel). B) Histology showing edema and inflammatory infiltrate associated with topical application of PMA (48 hours; Bar = 1 mm). C) Aggressive lymphoma in TAX-LUC mice from intravenous administration of con A. D) Histology is H/E stained sections of bioluminescent tumors in the cervical lymph nodes and small intestine of a con A treated TAX-LUC mouse.