The 5' and 3' junctional sequences of the same HIV provirus in Mre11-deficient cells. Junctions between both ends of HIV provirus and the host DNA were analyzed together in Mre11-deficient cells transduced with the HIV-based vector. Three cases including abnormal junctions are shown. In each case, the integrated HIV provirus (top) and the host genome (bottom) are compared. Proviral sequences are in lower case. Inserted abnormal nucleotides are shown in bold. The GT dinucleotides and primer binding site (PBS) sequences are underlined. Squares indicate short repeats flanking the provirus.