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Table 2 Inhibition of HIV-1 mediated cell-cell fusion by gp41 MPR derived peptides

From: Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection

 

IC50g

(nM, Mean ± S.D.)

 

IC50

(nM, Mean ± S.D.)

N36

>1000

LZ

> 1000

P1

913 ± 13.6

P1 + LZ

923.4 ± 11.7

T20

78 ± 5.6

T20 + LZ

579 ± 3.5

P5

60 ± 2.

P5 + LZ

61 ± 1.5

P5L

90 ± 1.7

P7

560 ± 10.7

  1. Note: Peptides P5L and P7 are recombinants the other chemically synthesized
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Retrovirology

ISSN: 1742-4690

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