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Figure 5 | Retrovirology

Figure 5

From: Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection

Figure 5

Inhibition of replication of T20-resistant HIV-1 strains. Inhibition of the replication of two T20-sensitive (pre-ENF, JRCSF) and two T20-resistant strains (ENF-1 and ENF-2) by P5 was studied in comparison with T20. P5 (open symbols) showed strong inhibitory activities against T20-resistant strains as compared with T20 (closed symbols). Sensitivity to P5 and T20 was measured in a single-cycle assay. Each point represents the mean IC50 value of at least three independent experiments (bars represent standard errors).

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Retrovirology

ISSN: 1742-4690

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