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Table 5 Analysis of inhibition of pseudotype infection by BMS-378806

From: The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

  Spl BS SB Bv1v3 Bv1v2 Sv1v3 Sv1v2 Br (N283T) Spl (T283N) DS17 DS17 (N283T) BaL HxB
Br <0.001 0.598 <0.001 0.044 <0.001 <0.001 0.002 0.620 <0.001 0.003 0.107 0.456 0.002
Spl   <0.001 0.916 <0.001 0.001 0.239 0.521 <0.001 0.162 <0.001 <0.001 <0.001 0.010
BS    <0.001 0.003 <0.001 <0.001 <0.001 0.392 <0.001 0.040 0.422 0.688 <0.001
SB     <0.001 0.039 0.390 0.610 0.002 0.323 <0.001 <0.001 0.003 0.090
Bv1v3      <0.001 0.001 0.002 0.608 <0.001 <0.001 <0.001 0.047 0.044
Bv1v2       <0.001 0.002 0.014 <0.001 <0.001 <0.001 <0.001 0.006
Sv1v3        0.456 0.044 0.115 <0.001 <0.001 <0.001 <0.001
Sv1v2         0.093 0.196 <0.001 <0.001 <0.001 0.003
Br(N283T)          0.059 0.016 0.193 0.722 0.141
Spl(T283N)           <0.001 <0.001 <0.001 <0.001
DS17            0.457 0.368 <0.001
DS17(N283T)             0.338 <0.001
BaL              <0.001
  1. Significance (p) values were obtained with an F test; p values below 0.05 were considered significant (shown in bold) an indicate rejection of the null hypothesis of a single best fit curve for both data sets.