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Table 4 Analysis of Env-mediated fusogenicitya.

From: The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

  Log10 [Ymax] (95% confidence limit) Time to reach 1.0E+4 RLU/secb Time to reach 1.0E+5 RLU/secb Difference
Br 5.94 (5.76–6.12) 99 163 64
Spl 5.43 (5.01–5.85) 161 307 146
BS 5.83 (5.65–6.01) 106 178 72
SB 5.59 (5.49–5.70) 175 312 137
Br(N283T) 5.93 (5.74–6.12) 104 171 67
Spl(T283N) 5.50 (5.12–5.88) 175 323 148
Bv1v3 5.93 (5.71–6.14) 109 180 71
Bv1v2 5.62 (5.43–5.81) 137 243 106
DS17 5.65 (5.44–5.86) 125 220 95
DS17(N283T) 5.61 (5.32–5.89) 121 215 94
BaL 5.70 (5.51–5.89) 122 211 89
  1. aNon-linear regression analysis was performed using an exponential model (Ymax, estimated maximal response in RLU/second) with background-subtracted data comprising 60–420 minutes after initiation of co-culture.
  2. bEstimated time is expressed in minutes.