Table 3 IC₅₀ values obtained in inhibition experiments^a.

Br

119 (58–246)

173 (129–230)

195 (157–298)

15 (9.4–23)

3.8 (2.2–6.5)

BS

79 (60–102)

140 (113–172)

155 (83–289)

20 (13–31)

1.8 (0.9–3.7)

Bv1v3

94 (55–158)

227 (110–468)

245 (156–387)

8.2 (5.7–12)

21 (12–36)

Bv1v2

22 (13–36)

224 (174–288)

155 (123–195)

4.8 (3.5–6.6)

48 (9.8–231)

Br(N283T)

60 (32–114)

166 (102–271)

221 (148–329)

13 (4.6–35)

7.2 (2.2–24)

Spl

5.7 (2.3–14)

37 (19–71)

27 (17–43)

1.8 (1.3–2.7)

16 (6.7–39)

SB

11 (6.4–18)

83 (53–129)^b

41 (30–56)^b

2.0 (1.2–3.5)

25 (12–50)

Sv1v3

n.d.

n.d.

n.d.

0.9 (0.6–1.3)

n.d.

Sv1v2

n.d.

n.d.

n.d.

1.2 (0.7–2.2)

n.d.

Spl(T283N)

11 (7.3–18)

n.d.

n.d.

0.9 (0.7–1.3)

n.d.

DS17

5.4 (3.8–7.7)

210 (160–274)^b

92 (73–116)^b

41 (29–58)

4.1 (2.7–6.2)

DS17(N283T)

5.1 (4.0–6.4)

155 (119–202)

104 (72–150)

32 (24–41)

2.6 (1.0–6.6)

BaL

n.d.

102 (85–122)

124 (103–149)

29 (15–59)

58 (14–241)

HxB

n.d.

n.d.

n.d.

3.9 (2.8–5.4)

1.6 (0.7–3.6)