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Figure 5 | Retrovirology

Figure 5

From: The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Figure 5

Sensitivity of pseudotypes to the entry inhibitor BMS-378806. Pseudotypes were incubated for 1 h. at 37°C with the gp120-targeted small molecule BMS-378806 and then the mixture was added to HOS-CD4-CCR5 cells. Pseudotypes containing BR, BR(N283T), BS and Bv1v3 Env were significantly less sensitive than those with SPL, SPL(T283N), SB, Sv1v3 or Sv1v2, while Bv1v2 displayed an intermediate sensitivity. DS17 and DS17(N283T) did not differ between them but showed reduced sensitivity to BMS-378806 as compared to the BR and Env with related phenotype. Data from a representative experiment repeated at least 4 times with similar results are shown.

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