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Figure 1 | Retrovirology

Figure 1

From: The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Figure 1

Schematic representation of chimeric and mutant Env. Chimeric Env constructs between brain- and spleen-derived Env of one individual were made to map the viral determinants of phenotypic changes. Single mutants were constructed to test for the role of N283 and T283 on the phenotypes observed.

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