Figure 5

Conserved folding among Tat variants. (A) Conserved folding between Tat Bru (bottom) and Tat Eli (top): Black represents pair of residues with at least one experimental NMR constraints between them, red represents pairs of amino acids with a distance less than 5 Å in the calculated structures and yellow represents pairs of amino acids with both experimental NMR constraints and a calculated distance less than 5 Å. (B) Contacts between the different regions of Tat Eli: the figure shows the regions that have one or more contact(s) and the number of contacts between them including or excluding the i, i+1 contacts. Red symbols in the lower triangle show regions that have three or more inter-region NMRconstraints. (C) Contour plot showing connectivities between Hβ of Cys 25 and Hδ of Pro 99 and Hβ of Ser 93 and Hβ of Asp 98 (left panel) between the aromatic ring protons of Tyr 47 and Hδ of Leu 69 (right panel).