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Figure 2 | Retrovirology

Figure 2

From: RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus

Figure 2

Proposed HAAmiRNA human target genes. (A) Complementary base-pairing between the HIVaINR antisense RNA site 1 (HAAmiRNA1) from nucleotides (nt) ~225–250 [14] and mRNA sequence encoding the interleukin-2 receptor gamma chain (IL-2RG or γC) from nt 6161–6198 in the 3' UTR (upper) and from nt 3103–3133 in an intronic region (lower). The human IL-2RG sequence was obtained from the NCBI GenBank AY692262. (B) Both strands of HAAmiRNA 1,1* target complementary sites in human interleukin-15 (IL-15) mRNA. HAAmiRNA 1 nt 225–250 [14] target IL-15 nt 1146–1166 and IL-15 nt 857–878, underlined (upper). The opposite strand HAAmiRNA 1* (yellow star) also targets sites in IL-15 mRNA, as indicated. IL-15 sequence is GenBank NM172174 transcript variant 1. Purple dots indicate proposed siRNA sequence. (C) HAAmiRNA site 2 from nt 271–297 [14] complementary base-pairing to human fragile × mental retardation protein mRNA (HsFMR1) is compared with the interaction between HsFMR1 and human miRNA-194 [48]. (D) HAAmiRNA site 3 from nt 341–369 [14] complementary base-pairing to human interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) mRNA at site 2 is compared to human miRNA-146a [77]. (E) The Mfold structure formed between HAAmiRNA1 and IL-2RG mRNA [31–33].

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