Figure 1

Secondary structure of HIVaINR antisense RNA[14] predicted by enhanced Mfold [31–33]. This is one of 19 structures predicted, but was chosen to illustrate the extensive duplex structure of the HIVaINR antisense RNA[14], with the predicted microRNA sites 1, 2, and 3 indicated. HAAmiRNA site 1 has complementary sequence to multiple sites in mRNA of the interleukin-2 receptor (IL-2R) gamma chain, also called the common γ chain, and to sites in the mRNA of interleukin-15 (IL-15). HAAmiRNA site 2 has complementary sequence to fragile-X mental retardation protein (FMR1) mRNA. HAAmiRNA site 3 has complementary sequence to sites in the interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) mRNA. Discussed in text.