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Table 3 Calculated ΔG values (kcal/mol at 37°C) for lentiviral SL1 region folding.

From: Regulation of primate lentiviral RNA dimerization by structural entrapment

 

SL1 version

nts folded

ΔG

HIV-2

short

408–436

-10.2

HIV-2

stem B

392–444

-18.2

HIV-2

extended stem B

392–449 a

-36.4

SIV

short

409–433

-7

SIV

stem B

393–445

-15.9

HIV-1

short

248–270

-6.7

HIV-1

stem B

243–277

-10.9 b

  1. The indicated energies are given for the most stable (initial ΔG value) secondary structure.
  2. a: nts 437 and 438 have been substituted by seven nts (Figure 6C). Thus nt 444 would be numbered 449 in this mutated sequence.
  3. b: The indicated energy is given for the structure described in Figure 5C that was obtained with a constrained 243–277 base pair. Without constraint, the lower part of stem C in the most stable structure folds with a 243–272 base pair (as studied in [48]).