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Figure 6 | Retrovirology

Figure 6

From: Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

Figure 6

Proposed model for the mechanism of dominant negative effect elicited by CycT1-U7. Wild type CycT1 forms a complex with Cdk9 as an active P-TEFb, and interacts with Tat and TAR RNA. Alternatively, CycT1-U7 associates with Tat but the CycT-U7/Tat complex is immediately degraded via an ubiquitin-dependent proteasomal pathway. This degradation can be prevented using proteasome inhibitors.

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