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Figure 7 | Retrovirology

Figure 7

From: Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities

Figure 7

The IFN-induced block occurs early in the MLV replication cycle. OMK cells were treated or not with 1000 U/ml of IFN-β and challenged 24 h later with DNase-treated GFP-expressing SIVmac (SIV), HIV-1 (HIV), N-, B-, or NB-tropic MLV vectors. The same experiment was performed in parallel in the presence of AZT at 5 μM during infections. Total DNA was extracted 6 h post-transduction and the amount of reverse transcripts was estimated by PCR using GFP primers. A PCR on CypA was also performed as a control.

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