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Table 3 R5 envelopes sensitivity to 2G12 neutralization and conservation of critical potential N-linked glycosylation sites.

From: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Envelope   2G12 sensitivity N295 N332 N339 N386 N392 N448
NA20 B59 +/- + + + + + +
  B76 + + + + + + +
  B501 +/- + + + + + +
  LN3 + + + + + + +
  LN8 + + + + + + +
  LN10 + + + + + + +
  LN14 + + + + + + +
  LN16 + + + + + + +
NA420 B13 - + + - - + +
  B33 - + + - - + +
  B42 +/- + + - + + +
  LN40 + + + - + + +
  LN85 - + + - + + +
NA118 B12 + + + + + + +
  LN27 + + + + + + +
  LN33 + + + + - + +
NA176 B93 + + + + + + +
NA353 B27 - + + + + + +
P-1114 C95-65 +/- + + - + + +
  C96-26 +/- + + + + + +
  C98-15 + + + + + + +
  C98-18 + + + + + + +
  C98-27 + + + + + + +
  C98-28 + + + + + + +
  C98-67 + + + + + + +
P3 Q3 164 1.4 + + + + + + +
  Q3 180 6.4 +/- + + + + + +
  SQ3 196 10.1 + + + + + + +
  SQ3 197 9.3 + + + + + + +
  SQ3 199 8.5 + + + + + + +
P31 Q31 350.1 +/- + + + + + +
  Q31 351.6 +/- + + + + + +
  SQ31 308.2 +/- + + + + + +
P43 Q43 378.2 - + + + + + -
  SQ43 380.1 - + + + + + -
  SQ43 380.4 - + + + + + -
Controls AD8 +/- + + + + + +
  SF162 + + + + + + +
  YU2 - + + - + + +
  JRFL + + + + + + +
  JRCSF + + + + + + +
  1. For 2G12 sensitivity; -, IC50 > 50 μg/ml; +/-, IC50 20–50 μg/ml; +, IC50 < 20 μg/ml.
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