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Table 2 Non-parametric two-tailed Spearman analysis for correlations between R5 envelope macrophage-tropism and sensitivity to entry inhibitors.

From: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Inhibitor/Antibody Target of reagent Stage of entry blocked3. Correlation with Macrophage-tropism (p Values)
Q4120 CD4 env: CD4 interactions <0.0001**
sCD4 gp120, CD4bs env: CD4 interactions <0.0001**
PRO 542 (IgG-CD4) gp120, CD4bs env: CD4 interactions <0.0001**
BMS-378806 gp120, CD4bs channel1. env: CD4 interactions 0.0002**
b12 gp120, overlapping CD4bs2.   0.6843
TAK779 CCR5 env: CCR5 interactions 0.7964
SCH350581 CCR5 env: CCR5 interactions 0.7587
2D7 CCR5 env: CCR5 interactions  
2G12 gp120 glycan env: CCR5 interactions 0.0138*
T20 gp41 conformational changes gp41 conformational changes 0.7061
2F5 gp41 membrane proximal region gp41 conformational changes4. 0.3741
4E10 gp41 membrane proximal region gp41 conformational changes4. 0.3502
  1. 1. BMS-378806 binds to a hydrophobic channel deep in the channel targeted by CD4 [42].
  2. 2. Mab b12 binds an epitope that overlaps the CD4bs [57].
  3. 3. Mab 2G12 binds to a glycan on gp120. 2G12 blocks env:CCR5 interactions but may also block earlier stages of entry [73].
  4. 4. Mabs 2F5 and 4E10 block gp41 conformational changes but may also block earlier stages of entry [73].
  5. * Significant (p ≤ 0.05).
  6. ** Highly significant (p ≤ 0.01)
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