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Table 1 Macrophage tropism of R5 envelopes studied.

From: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Patient Number Envelope Macrophage Infectivity (%)a Patient Number Envelope Macrophage Infectivity (%)a
NA20 B59 16.9 b P1114 C95-65 0.029
  B76 0.179   C96-26 0.097
  B501 51.6   C98-15 32.4
  LN3 <0.001   C98-18 2.21
  LN8 <0.001   C98-27 0.144
  LN10 0.030   C98-28 0.004
  LN14 0.025   C98-67 0.003
  LN16 0.036 P3 Q3 164 1.4 0.002
NA420 B13 0.335   Q3 180 6.4 0.003
  B33 3.35   SQ3 196 10.1 0.012
  B42 0.559   SQ3 197 9.3 0.338
  LN40 0.009   SQ3 199 8.5 0.003
  LN85 0.026 P31 Q31 350.1 0.05
NA118 B12 0.006   Q31 351.6 0.02
  LN27 0.023   SQ31 308.2 0.02
  LN33 0.023 P43 Q43 378.2 0.03
NA176 B93 8.2   SQ43 380.1 0.6
NA353 B27 12.6   SQ43 380.4 9.63
    Controls AD8 4.60
     SF162 6.25
     YU2 6.36
     JRFL 3.27
     JRCSF 0.011
  1. aMacrophage infectivity as a percent of infectivity recorded on HeLa TZM-BL cells. Most of this data is derived from that presented in Peters et al. [27] with the addition of SQ43 380.4.
  2. bBolded percentages indicate envelopes that were designated as macrophage-tropic i.e. >0.5% of infectivity for HeLa TZM-BL cells.
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