Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Table 1 Macrophage tropism of R5 envelopes studied.

Patient Number	Envelope	Macrophage Infectivity (%)^a	Patient Number	Envelope	Macrophage Infectivity (%)^a
NA20	B59	16.9 ^b	P1114	C95-65	0.029
	B76	0.179		C96-26	0.097
	B501	51.6		C98-15	32.4
	LN3	<0.001		C98-18	2.21
	LN8	<0.001		C98-27	0.144
	LN10	0.030		C98-28	0.004
	LN14	0.025		C98-67	0.003
	LN16	0.036	P3	Q3 164 1.4	0.002
NA420	B13	0.335		Q3 180 6.4	0.003
	B33	3.35		SQ3 196 10.1	0.012
	B42	0.559		SQ3 197 9.3	0.338
	LN40	0.009		SQ3 199 8.5	0.003
	LN85	0.026	P31	Q31 350.1	0.05
NA118	B12	0.006		Q31 351.6	0.02
	LN27	0.023		SQ31 308.2	0.02
	LN33	0.023	P43	Q43 378.2	0.03
NA176	B93	8.2		SQ43 380.1	0.6
NA353	B27	12.6		SQ43 380.4	9.63
			Controls	AD8	4.60
				SF162	6.25
				YU2	6.36
				JRFL	3.27
				JRCSF	0.011

^aMacrophage infectivity as a percent of infectivity recorded on HeLa TZM-BL cells. Most of this data is derived from that presented in Peters et al. [27] with the addition of SQ43 380.4.
^bBolded percentages indicate envelopes that were designated as macrophage-tropic i.e. >0.5% of infectivity for HeLa TZM-BL cells.

ISSN: 1742-4690