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Figure 7 | Retrovirology

Figure 7

From: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Figure 7

Intrapatient variation of HIV-1 R5 envelope macrophage-tropism and sensitivity to reagents that inhibit gp120 interactions with CD4 and CCR5. Brain-derived envelopes (light symbols) from patient NA420 (left panels) and NA20 (right panels) were more sensitive to PRO 542, b12, TAK779 and SCH350581, but more resistant to anti-CD4, Q4120, compared to LN-derived envelopes (dark symbols). NA420 envelopes tested were B13 (light squares), B33 (light triangles), B42 (light diamonds), LN85 (dark circles) and LN40 (dark triangles). NA20 envelopes tested were B59 (light squares), B76 (light triangles), B501 (light diamonds), LN3 (crosses), LN8 (dark circles), LN10 (dark diamonds), LN14 (dark triangles) and LN16 (dark squares).

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