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Figure 3 | Retrovirology

Figure 3

From: Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Figure 3

Sensitivity of HIV-1 R5 envelopes to reagents that interfere with gp120:CCR5 interactions. Pseudovirions carrying envelopes encoded by envelope genes amplified from patient samples were tested for sensitivity to inhibition by (A) TAK779, (B) SCH350581 and (C) anti-CCR5, 2D7. Macrophage-tropic envelopes (light symbols) and non-macrophage-tropic envelopes (dark symbols) were examined. Statistical analysis showed no overall correlation between macrophage-tropism and sensitivity to TAK779 or SCH350581 (Table 2).

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