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Figure 1 | Retrovirology

Figure 1

From: HIV-1 latency in actively dividing human T cell lines

Figure 1

Schematic overview of HIV-1 variants used in this study. In the HIV-rtTA variant, the rtTA gene is inserted in place of the nef gene and TetO binding sites are inserted in the HIV-1 promoter. Inactivation of the Tat-TAR axis is obtained by mutations in the R region and the Tat protein. The shNef expression cassette is inserted in the U3 region. The Tat inactivating mutation (indicted by X) in HIV-rtTA has been restored in the HIV-rtTA Tatwt variant.

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