Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells

Retrovirology

Table 1 Comparison of HBZ-SI and Tax mRNA

	ACs	ATL cells	Cell lines	Relative intensity^‡ (Acs:ATL : cell lines)
HBZ-SI
raw data*	0.04 ± 0.06	1.13 ± 1.41	14.01 ± 23.2	(1: 28: 350) ^§
adjusted*	3.34 ± 4.71	19.82 ± 54.31	19.02 ± 22.2	(1: 6: 6)
Tax
raw data*	0.009 ± 0.01	0.01 ± 0.02	590.0 ± 989.1	(1: 1: 6600) ^#
adjusted*	0.9 ± 1.2	0.06 ± 0.01	813.0 ± 1460.0	(1: 1/15: 900) ^§
HBZ-SI/Tax ^†	3.7 ± 12.0	330 ± 440^&	0.023 ± 0.125
	low HBZ/low Tax	high HBZ/low Tax	high HBZ/very high Tax

The proviral adjusted data was calculated by dividing the raw data by HTLV-1 proviral load. Each adjusted value and HBZ-SI/Tax show the characteristic features of the mutual expression patternbetween HBZ-SI and Tax from the viewpoint of relative and absolute transcript levels. * × 104 † ratio ‡ relative expression intensity among three groups §P < 0.01 among three cell types # P < 0.01 among ATL cells and cell lines3); P < 0.01 for ACs and cell lines.

ISSN: 1742-4690