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Figure 7 | Retrovirology

Figure 7

From: Distinct efficacy of HIV-1 entry inhibitors to prevent cell-to-cell transfer of R5 and X4 viruses across a human placental trophoblast barrier in a reconstitution model in vitro

Figure 7

The fusion inhibitor T20 does not quantitatively increases transfer of green fluorescence from the effector to target CD4 positive Bewo cell cytoplasms. Green fluorescence from the experiment on slides (figure 6) was quantified in light units (pixels) inside and outside CD4 positive BeWo cells. Figure 7A (upper panel) represents the green fluorescence in PBMCs that have adhered on the surface of BeWo cells (outside). Figure 7B (lower panel) represents green fluorescence that has been transferred from HIV-1 LAI infected PBMCs into BeWo cells (inside). The figure shows averaged green fluorescence intensities from 3 differents fields in the absence of drug, in the presence of 10 μM T20 or 800 nM AMD3100. Histograms represent means and the error bars are standard deviation to the mean. There is no difference statistically significant between the three different conditions compared (no drug, +T20, +AMD3100).

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Retrovirology

ISSN: 1742-4690

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