Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase

Retrovirology

Table 1 Amino acid variation at codons 40 and 43 in HIV-1 reverse transcriptase

Codon 40	Number	pct of mut	pct of total	Codon 43	Number	pct of mut	pct of total
D	732	38.0%	0.452%	E	4262	38.1%	2.631%
F	541	28.1%	0.334%	Q	2444	21.8%	1.509%
E/D	264	13.7%	0.163%	N	1516	13.5%	0.936%
K	54	2.8%	0.033%	K/E	836	7.5%	0.516%
K/E	53	2.8%	0.033%	K/Q	699	6.2%	0.432%
A	50	2.6%	0.031%	R	379	3.4%	0.234%
E/Q	33	1.7%	0.020%	K/N	333	3.0%	0.206%
E/G	27	1.4%	0.017%	K/R	285	2.5%	0.176%
E/A	27	1.4%	0.017%	E/Q	122	1.1%	0.075%
Q	21	1.1%	0.013%	K/D/N/E	41	0.4%	0.025%
V	21	1.1%	0.013%	A	37	0.3%	0.023%
V/F	10	0.5%	0.006%	T	36	0.3%	0.022%
S/F	10	0.5%	0.006%	K/H/N/Q	34	0.3%	0.021%
<10 examples	81	4.2%	0.050%	M	33	0.3%	0.020%
K/T	20	0.2%	0.012%
Total	1924	100.0%	1.188%	S	19	0.2%	0.012%
N/H	14	0.1%	0.009%
				K/A/T/E	10	0.1%	0.006%
				<10 examples	69	0.6%	0.043%
				Total	11189	100.0%	6.908%

In a total of 161974 sequences the amino acid variation at codons 40 and 43 in reverse transcriptase was determined. Shown are the percentages of the specified amino acid change of all mutations at that position (pct of mut) and in the total population (pct of total).

ISSN: 1742-4690