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Table 1 P24 production in HIV-1 persistently-infected cell lines exposed to TNF-α or PMA

From: Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway

Cell line and treatment

0 h

24 h

48 h

J1.1 Cells

14.07 ± 0.01

14.14 ± 0.05

18.26 ± 0.80

J1.1 Cells + TNF α

14.08 ± 0.01

12.86 ± 0.90

152.04 ± 1.50

U1 Cells

1.06 ± 0.03

1.60 ± 0.03

4.18 ± 1.11

U1 Cells + PMA

1.05 ± 0.03

51.96 ± 9.20

191.76 ± 0.48

  1. HIV-1 persistently-infected lymphoid J1.1 and monocytic U1 cells were treated with TNF-α and PMA respectively in order to stimulate viral replication. P24 antigen was determined at 0, 24 and 48 h in cell supernatants by ELISA (HIVAG-1 Monoclonal, Abbot Laboratories). Values correspond to p24 antigen per 200,000 cells, expressed in J1.1 as pg/ml and in U1 Cells as ng/ml.