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Table 3 Phosphatidylcholine and cholesterol content of lentviral vectors is increased by co expression of ABCB4 during production.

From: Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

 

nmol PC/μg p24

nmol cholesterol/μg p24

ABCB4 wild type (n = 6)

51 ± 26

40 ± 19

ABCB4mutant (n = 6)

4 ± 3*

9 ± 2*

Vector (n = 3)

6 ± 4*

8 ± 1*

  1. PC and cholesterol content of lentiviral vector preparations produced with co-expression of ABCB4, ABCB4mutant or no co-expression. The values were adjusted for the amount of p24-gag antigen per sample. *Significant difference p < 0.01 compared to ABCB4 co-expression. Mean values are presented ± SD.
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Retrovirology

ISSN: 1742-4690

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