Skip to main content

Table 3 Phosphatidylcholine and cholesterol content of lentviral vectors is increased by co expression of ABCB4 during production.

From: Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

  nmol PC/μg p24 nmol cholesterol/μg p24
ABCB4 wild type (n = 6) 51 ± 26 40 ± 19
ABCB4mutant (n = 6) 4 ± 3* 9 ± 2*
Vector (n = 3) 6 ± 4* 8 ± 1*
  1. PC and cholesterol content of lentiviral vector preparations produced with co-expression of ABCB4, ABCB4mutant or no co-expression. The values were adjusted for the amount of p24-gag antigen per sample. *Significant difference p < 0.01 compared to ABCB4 co-expression. Mean values are presented ± SD.