Figure 1

Overview of 4 miRNAs overexpressed in ATL cells and their targeted mRNAs: TP53INP1, Smad5 and IRAK6/TRAF1. These genes are critically involved in pathways important for viral persistence and oncogenicity. Tax directly transactivates the miR-146a (through a NF-κB site) and miR-130b promoters. Only one of these pathways Tax→miR130b→TP53INP1→apoptosis has presently been demonstrated functionally.