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Figure 8 | Retrovirology

Figure 8

From: HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)

Figure 8

Proposed model for the transcriptional regulation of the hTERT core promoter during the HTLV-1-induced leukemic process (see Discussion). The early steps of the leukemic process during which HTLV-1 infected T-lymphocytes were expressing Tax and HBZ are characterized by the recruitment of transcriptional activators (TA) by Tax. Later, Tax expression is decreased and/or silenced and the TA become available to interact with HBZ/JunD complexes. In both cases, HBZ/JunD complexes are interacting with the Sp1 transcription factor bound to the GC boxes present in the hTERT core promoter.

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