Figure 2
From: Optimal design and validation of antiviral siRNA for targeting HIV-1
Validation of 41 siRNAs. The antiviral efficacy of each siRNA was tested against four HIV-1 infectious molecular clones: pNL4-2 (subtype B); 95MM-yIDU106 (subtype B'); 93IN101 (subtype C); or 93JP-NH1 (CRF01_AE). The potency of each siRNA was tested using the target mRNA cleavage assay (rightmost panel). The ability of each siRNA to cleave its target was evaluated by the target mRNA cleavage assay.