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Figure 1 | Retrovirology

Figure 1

From: Optimal design and validation of antiviral siRNA for targeting HIV-1

Figure 1

Conservations of siRNA target sequences among HIV-1 group M. (A) A total of 4,417,157 siRNA targets were generated from the 495 HIV-1 sequences, and their conservations within the HIV-1 genomes are represented using a color density plot. The line plot above the color chart represents the highest value in each position. (B) A detailed view of the three conserved regions; 5' LTR, the cPPT/CTS in the integrase gene, and 3' PPT. 'Position' indicates the 5'-most position of each 21-mer. The landmarks of the HIV-1 genome are adjusted to align at the center of the siRNAs by shifting 10 bp to the left. (C) Pie chart indicating the percentage of the 4,417,157 siRNA target sites at each conservation level.

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