Skip to main content
Figure 4 | Retrovirology

Figure 4

From: Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitroand provide a rationale to redesign antiretroviral treatment for feline AIDS

Figure 4

Integrase strand transfer inhibitors adopted in the present study. Panel A: Synthesis of CHI1010 (7) and CHI1019 (8). Reagents and conditions: i) AcCl, Et2AlCl, CH2Cl2, 0°C, 2 h. ii) benzyl or 4-fluorobenzyl bromide, NaH, DMF, 0°C, 30 min; iii) diethyl oxalate, dry C2H5ONa, THF, two separated steps in the same conditions: 50°C, 2 min, 250 W, 300 psi; iv) 2N NaOH, MeOH, rt, 1.5 h. Panel B: structure of Merck's compound L-870,810 (9).

Back to article page