Figure 2From: Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitroand provide a rationale to redesign antiretroviral treatment for feline AIDSAmino acid sequence alignment of the lentiviral integrase catalytic core domain (IN CCD). Amino acid sequences were aligned with BioEdit and alignments manually edited to eliminate gaps. FIV-Fca, FIV-Oma, and FIV-Pco refer to feline immunodeficiency viruses from domestic cat, Pallas' cat, and puma, respectively. The FIV-Fca clade is indicated by capital letters. The catalytic triad is marked by the black arrows. Blue arrows show the amino acids reported to confer significant cross-resistance to the major classes of IN strand transfer inhibitors. Small arrows show minor drug resistance mutations. Amino acid numbering refers to HIV-1 IN. The Pol IN CCD sequences aligned were from: immunodeficiency virus type-1 (HIV-1) [PDB: 1BL3C]; simian immunodeficiency virus, host: macaque (SIV-mac) [PDB: 1C6VC]; FIV-Fca: Petaluma (Pet) [REFSEQ: NP_040973.1], San Diego (SD) [Swiss-Prot: :P19028], TM2 [GenBank: AAA43071], BM3070 [GenBank: AAM13444], C36 [GenBank: AAT12494]; FIV-Oma: Oma-3 [GenBank: AAU20798.1]; FIV-Pco: PLV-1695 [GenBank: ABB29307.1] and PLV-14 [GenBank: AAA67168.1]. M2 and M3 are local field isolates of FIV-Fca, clade B (Pistello et al., 1997, sequences being submitted to GenBank).Back to article page