Macrophages | Â | Â | Â |
---|
Cells | EC50 (mM) | EC90 (mM) | TC50 (mM) |
Acutely infected | 3.7 (± 0.05) | 19.5 (± 0.5) | 60 |
Cronically infected | 6.3 (± 0.003) | 30 (± 0.6) | 60 |
Limphocytes
| Â | Â | Â |
Acutely infected | 7.4 (± 0.06) | 21.3 (± 0.6) | 50 |
- The geometric mean of p24 gag Ag production of replicates in each experiment was used to determine the effective drug concentration where 50% and 90% of viral replication is inhibited (EC50 and EC90, respectively), by linear regression of the log of the percent HIV-1-p24 production (compared to untreated controls) versus the log of the drug concentration. TC50: toxic concentration 50%; drug toxicity has been assessed in the absence of viral infection.