The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection

Shehu-Xhilaga, Miranda; Kent, Stephen; Batten, Jane; Ellis, Sarah; Van der Meulen, Joel; O'Bryan, Moira; Cameron, Paul U; Lewin, Sharon R; Hedger, Mark P

doi:10.1186/1742-4690-4-7

Table 2 Summary of testicular and epididymal histology for SIV and SHIV-infected macaques

From: The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection

Animal	Spermatogenesis	Testicular Interstitium	Epididymis
M1_SIVmac251	Full spermatogenesis	Normal macrophage numbers; no infiltrates	Sperm in lumen; macrophages and small sized mononuclear cell infiltrates in stroma
M2_SIVmac251	Spermatocytes and seminiferous cords only	Small numbers of scattered mononuclear cells; macrophage numbers appear normal	No cells in lumen; large sized mononuclear cell infiltrates in stroma; normal macrophage numbers
M3_SIVmac251	Some round spermatids present	Few macrophages; no infiltrates	No cells in lumen; numerous macrophages and focal mononuclear cell infiltrates
M4_SIVmac251	Elongating spermatids present; some tubules with lumen	Normal macrophage numbers; no infiltrates	Sperm and many spermatocytes and round spermatids in lumen; several very large mononuclear cell infiltrates in stroma
M5_SIVmac251	Spermatocytes and seminiferous cords only	Minor mononuclear cell infiltrates; macrophage numbers appear normal	No cells in lumen; medium sized mononuclear cell infiltrates in stroma; normal macrophage numbers
M6_SIVmac251	Full spermatogenesis	Normal macrophage numbers; no infiltrates	Sperm in lumen; no stromal infiltrates
M7_SHIVmn229	Full spermatogenesis	Normal macrophage numbers; no infiltrates	Sperm in lumen; numerous macrophages and scattered mononuclear cell infiltrates
M8_SHIVmn229	Spermatogonia and seminiferous cords only	Few macrophages; no infiltrates	No cells in lumen; no stromal infiltrates
M9_SHIVmn229	Spermatogonia and seminiferous cords only	Few macrophages; no infiltrates	No cells in lumen; no stromal infiltrates
M10_SHIVmn229	Elongating spermatids present; some tubules with lumen	Normal macrophage numbers; no infiltrates	No cells in lumen; numerous macrophages and scattered mononuclear cell infiltrates
M11_SHIVmn229	Spermatogonia and seminiferous cords only	Numerous macrophages in the interstitium and some focal mononuclear cell infiltrates	No cells in lumen; no stromal infiltrates
M12_SHIVmn229	Elongating spermatids present; spermatogenesis is disorganised	Normal macrophage numbers; no infiltrates	No sperm in lumen; degenerating spermatocytes and round spermatids in lumen; no stromal infiltrates

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ISSN: 1742-4690

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