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Table 2 Phenotypes of nef-deleted viruses isolated from SBBC members, and corresponding laboratory data

From: Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

Subject

Virus isolate

Date

Years post-infection

CD4 cells (cells/μl)

HIV RNA (copies/ml)

Replication in PBMC

Coreceptor usage

D36

D36II

6/5/95

14.4

N/A

1400

++

CCR5, CXCR4, (CCR2b)

 

D36III

8/2/96

15.2

609

1100

++

NT

 

D36IV

10/4/96

15.3

504

7700

++

NT

 

D36V

9/7/96

15.6

414

2600

++

NT

 

D36VI

23/10/96

15.8

432

1100

++

NT

 

D36VII

30/1/97

16.1

361

3200

++

NT

 

D36VIII

20/5/97

16.4

540

4000

++

CCR5, CXCR4, (CCR2b)

 

D36IX

23/12/97

17.0

390

7500

++

CCR5, CXCR4, (CCR2b)

 

D36X

15/7/98

17.6

325

N/A

++

NT

 

D36XI

22/1/99

18.1

N/A

N/A

++

CCR5, CXCR4, (CCR2b)

 

D36XVI

8/11/00

19.9

N/A

BD

++

CCR5

C18

C18(2)

26/7/93

9.8

N/A

N/A

+++

CCR5, (CCR3, Gpr15)

 

C18(3)

14/10/93

10.1

N/A

N/A

+++

NT

 

C18(4)

7/3/94

10.5

N/A

2804

+++

CCR5, (CCR3, Gpr15)

C54

C54III

7/11/94

10.3

2006

8200

+/-

CCR5, (CCR2b, CCR3)

 

C54IV

21/6/95

10.9

1504

3000

+/-

NT

 

C54 V

20/12/95

11.4

1054

400

+/-

NT

 

C54VI

4/3/96

11.7

1188

1500

+/-

NT

 

C54VII

19/6/96

11.9

972

3600

+/-

NT

 

C54VIII

16/9/96

12.2

1120

1800

+/-

CCR5, (CCR2b, CCR3)

 

C54X

3/3/97

12.7

882

3400

+/-

NT

 

C54XI

14/5/97

12.8

1286

N/A

+/-

NT

 

C54XII

11/8/97

13.1

1419

1700

+/-

NT

 

C54XIII

17/11/97

13.3

1054

N/A

+/-

NT

 

C54XIV

5/5/99

14.8

1288

1200

+/-

CCR5, (CCR2b, CCR3)

 

C54XV

6/3/00

15.7

840

1600

+/-

NT

C98

C98II

7/12/94

12.9

426

1000

++

CCR5, (CCR3)

 

C98III

9/10/95

13.8

576

670

++

NT

 

C98IV

7/2/96

14.1

435

200

++

NT

 

C98V

22/5/96

14.3

693

290

++

NT

 

C98VI

7/8/96

14.6

512

330

++

CCR5, (CCR2b, CCR3)

 

C98VII

4/11/96

14.8

646

690

++

NT

 

C98VIII

31/1/97

15.0

629

770

++

NT

 

C98IX

7/5/97

15.3

529

760

++

NT

 

C98X

27/8/97

15.6

612

170

++

NT

 

C98XI

26/11/97

15.8

400

N/A

++

NT

 

C98XII

30/9/98

16.7

N/D

N/A

++

NT

 

C98XIII

3/3/99

17.2

476

N/A

++

NT

 

C98XIV

9/11/99

17.8

585

BD

++

CCR5, (CCR2b, CCR3)

C64

C64IV

28/2/96

12.8

850

BD

+/-

CCR5

  1. Dates shown are day/month/year. CD4 cells were measured by flow cytometry. Plasma HIV-1 RNA was measured by COBAS Amplicor HIV-1 Monitor Version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.) prior to July 1999 and Version 1.5 after July 1999. HIV-1 RNA levels < 400 copies/ml (Version 1) or < 50 copies/ml (Version 1.5) were considered below detection. BD, below detection; N/A, not available; NT, not tested. +++, replication kinetics similar to wild type primary HIV strains; ++, reduced levels of replication and/or delayed replication kinetics compared to wild type primary HIV strains; +/-, levels of HIV replication barely detectable or not detectable by RT assays, but detectable by measurement of extracellular p24 antigen [40].