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Table 1 Distribution of CTL Responses (breadth and strength) between HIV proteins

From: Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC)

Protein

No. of Peptides

No. of OLP targeted at least once in the cohort (%)

No. of subjects with responses (%)

CTL strength (Mean ± SD) (SFC/106 PBMC)

 

B

C

B

C

B

C

B

C

Gag-p17*

17

17

14(82.4%)

16(94.1%)

32(53.3%)

43(71.7%)

610 ± 1185

964 ± 1340

Gag-p24

31

31

30(96.8%)

30(96.8%)

51(85.0%)

52(86.7%)

3155 ± 3894

2935 ± 3390

Gag-p15

19

19

12(63.2%)

13(68.4%)

32(53.3%)

34(56.7%)

767 ± 1495

698 ± 1290

Gag

67

67

56(83.6%)

59(88.1%)

55(91.7%)

54(90.0%)

4532 ± 5512

4597 ± 5073

Pol – Pro*#

21

21

12(57.1%)

6(28.6%)

22(36.7%)

11(18.3%)

437 ± 949

240 ± 729

Pol – RT*

59

59

40(67.8%)

47(79.7%)

46(76.7%)

53(88.3%)

1047 ± 1461

2104 ± 2691

Pol – Rnase*

17

17

9(52.9%)

12(70.6%)

14(23.3%)

33(55.0%)

250 ± 1066

562 ± 1258

Pol – Int

36

36

27(75.0%)

30(83.3%)

38(63.3%)

42(70.0%)

864 ± 1158

922 ± 1228

Pol*

133

133

88(66.2%)

95(71.4%)

52(86.7%)

58(96.7%)

2598 ± 3069

3828 ± 4090

Env-gp120*

68

68

28(41.2%)

39(57.4%)

32(53.3%)

38(63.3%)

690 ± 1445

1034 ± 2062

Env-gp41*

46

46

17(37.0%)

31(67.4%)

29(48.3%)

45(75.0%)

649 ± 1377

943 ± 1389

Env*

114

114

45(39.5%)

70(61.4%)

46(76.7%)

52(86.7%)

1339 ± 2040

1976 ± 2624

Nef

27

27

26(96.3%)

24(88.9%)

52(86.7%)

51(85.0%)

2727 ± 4305

2812 ± 4217

Rev

15

14

10(66.7%)

9(64.3%)

18(30.0%)

28(46.7%)

552 ± 1421

590 ± 1105

Tat

13

13

7(53.8%)

6(46.2%)

10(16.7%)

9(15.0%)

283 ± 1103

132 ± 496

Vpu*#

9

9

8(88.9%)

3(33.3%)

9(15.0%)

3(5.0%)

144 ± 535

24 ± 115

Vpr

11

11

10(90.9%)

11(100%)

27(45.0%)

27(45.0%)

532 ± 1070

522 ± 988

Vif

24

24

13(54.2%)

19(79.2%)

20(33.3%)

37(61.7%)

576 ± 1627

762 ± 1483

Total *

413

412

263(63.7%)

296(71.8%)

60(100%)

60(100%)

13283 ± 14223

15242 ± 14353

  1. 1. * denotes a significant difference in responses targeting clade B and C OLPs (p value < 0.05, paired t test).
  2. 2. # denotes that the CTL responses to clade B OLPs targeting protease and Vpu are significantly stronger and broader than to clade C OLPs