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Figure 5 | Retrovirology

Figure 5

From: Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression

Figure 5

Influence of IκBα over-expression on HIV-LTR transactivation. Resting CD4+ T cells were transfected with LTR-LUC vector together with (a) pcDNA3.1 and/or CMV-Tat expression vectors or (b) pcDNA3.1 and/or CMV-Tat and/or CMV-IκBα expression vectors, as indicated. Cells were treated with LMB immediately after transfection and/or with PMA two hours after transfection, as indicated. Luciferase activity was measured 18 hours after transfection. Numbers on the top of the bars represent fold transcriptional activity relative to unstimulated T cells transfected with pcDNA3.1.

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