Antigen-presenting particle technology using inactivated surface-engineered viruses: induction of immune responses against infectious agents

Mosca, Joseph D; Chang, Yung-Nien; Williams, Gregory

doi:10.1186/1742-4690-4-32

Table 4 Particle-induced Antibody Formation

From: Antigen-presenting particle technology using inactivated surface-engineered viruses: induction of immune responses against infectious agents

	Particle Preparations
Expt.	Virus	Modification	Relative Optical Density Units
1.			HSV-1 Coated			HSV-2 Coated			HIV-1 Coated
			9D	13D	16D	9D	13D	16D	9, 13, 16 Days
	None	None	0.089	0.034	0.02	0.006	0.006	0.005	0.006
	HSV-2	non-engineered	0.050	0.019	0.010	0.006	0.006	0.005	0.005
		B7-engineered	3.6	16.5	7.9	0.2	0.3	0.3	0.004
		B7+antiCD3	3.7	3.7	6.8	0.3	0.4	0.7	0.005
2.			HSV-1 Coated			HSV-2 Coated			HIV-1 or VSV Coated
			3D	6D	10D	3D	6D	10D	3D	6D	10D
	None	None	0.007	0.005	0.005	0.005	0.005	0.005	0.005	0.005	0.063
		PHA/IL-2	0.005	0.012	0.7	0.005	0.004	0.1	0.007	0.007	0.005
	HSV-2	non-engineered	0.002	1.4	5.2	0.008	1.3	0.8	0.003	0.003	0.001
		antiCD3	0.2	1.9	10.0	0.2	1.7	3.0	0.003	0.004	0.005
		B7-engineered	0.001	0.9	7.5	0.003	0.7	1.5	0.003	0.008	0.004
		B7+antiCD3	0.001	1.3	6.5	0.025	1.2	7.3	0,004	0.005	0.004
	HIV-1	non-engineered	0.002	0.006	0.006	0.004	0.019	0.004	0.004	0.004	0.004
		B7-engineered	0.001	0.008	0.023	0.004	0.004	0.021	0.004	0.003	0.002
		B7+antiCD3	0.008	0.007	0.031	0.004	0.004	0.027	0.006	0.001	0.005
3.			Influenza-A Japan Coated			Influenza-B Taiwan Coated			Influenza-B Russian Coated
			11D	15D		11D	15D		11D	15D
	None	None	0.016	0.030		0.005	0.037		0.006	0.007
		PHA/IL-2	0.16	0.030		0.010	0.046		0.018	0.007
	Influenza-A	non-engineered	0.010	0.005		0.010	0.046		0.018	0.007
	Japan	antiCD3	0.014	0.004		0.22	0.29		0.21	0.15
		B7-engineered	0.011	0.004		0.008	0.006		0.014	0.005
		B7+antiCD3	0.012	0.006		0.009	0.011		0.023	0.006
	Influenza-A	non-engineered	0.013	0.004		0.006	0.005		0.003	0.004
	PR8	antiCD3	0.009	0.004		0.010	0.008		0.15	0.16
		B7-engineered	0.40	0.34		0.004	0.004		0.017	0.011
		B7+antiCD3	0.10	0.031		0.008	0.004		0.009	0.003
	Influenza-B	non-engineered	0.013	0.004		0.004	0.004		0.003	0.005
	Taiwan	antiCD3	0.010	0.007		0.008	0.005		0.007	0.004
		B7-engineered	0.16	0.09		0.005	0.004		0.004	0.004
		B7+antiCD3	0.011	0.002		0.005	0.005		0.007	0.003

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ISSN: 1742-4690

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